Amelioration of Oxidative Damage Induced in Gamma Irradiated Rats by Nano Selenium and Lovastatin Mixture

Nano selenium-Lovastatin mixture (Lov-Se) has antioxidant and free radical scavenging activities. A laboratory preparation of nano selenium-lovastatin mixture was examined against oxidative injury in gamma irradiated rats. Rats were exposed to whole body gamma radiation (2 Gy every 3 days up to total dose of 8 Gy) and received daily oral administration of 1ml Lov-Se ( 20 mg/kg/day/Lov and 0.1 mg kg/day/Se) for 14 days parallel with radiation exposure. Animals were divided into 4 equal groups as following: Normal control, Lov-Se, irradiated and irradiated + Lov-Se. The results obtained reveals that, TBARS, protein carbonyl levels, XO, CAT and SOD activities were significantly ameliorated in heart of irradiated + Lov-Se group as compared to irradiated rats. Also, heart GSH, NO levels, XDH, GSH-Px activities and blood Se level were significantly improved. It was concluded that the proper administration of Lov-Se mixture might reduce the radiation-induced heart injury via amending the antioxidant molecules and decreasing lipid and protein oxidation.